Decreased Lung Fibroblast Growth Factor 18 and Elastin in Congenital Diaphragmatic Hernia and Models
نویسندگان
چکیده
1 Inserm U651, Créteil, France ; Université Paris 12, Faculté de Médecine, Institut Mondor de Médecine Moléculaire, Créteil, France. 2 Université Paris-Descartes, Faculté de Médecine ; AP-HP ; Hôpital Necker-Enfants Malades, Maternité, Paris, France. 3 Université Paris-Descartes, Faculté de Médecine ; AP-HP ; Hôpital Necker-Enfants Malades, Service de Fœtopathologie, Paris, France. 4 Department of Pediatrics-Division of Neonatology, University of Alberta, Edmonton, Canada.
منابع مشابه
Decreased lung fibroblast growth factor 18 and elastin in human congenital diaphragmatic hernia and animal models.
RATIONALE Lung hypoplasia in congenital diaphragmatic hernia (CDH) seems to involve impaired alveolar septation. We hypothesized that disturbed deposition of elastin and expression of fibroblast growth factor 18 (FGF18), an elastogenesis stimulus, occurs in CDH. OBJECTIVES To document FGF18 and elastin in human CDH and ovine surgical and rat nitrofen models and to use models to evaluate the b...
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